Lamin-B1 (RBT-LMNB1), RMab

Description

Lamin-B1 is an intermediate filament protein that in humans is encoded by the gene LMNB1. B-type Lamin along with A-type Lamin line the inner surface of the nuclear envelope and form a dynamic structure that is disassembled and reassembled each time a cell enters mitosis. Lamin-B1 plays a central role in chromatin organization, gene positioning, DNA replication and repair, cell cycle progression, stress responses, proliferation and differentiation. Lamin-B1 loss is associated with cellular senescence and a broad range of aging-related diseases such as cardiovascular diseases and cancers. Recent studies showed Lamin-B1 deficiency promotes Lung Cancer development and metastasis by epigenetic derepression of RET, as well as malignancy and poor prognosis in Gastric Cancer. It has been observed that Lamin-B1 levels are reduced in Lung Cancer patients compared to normal Lung tissue and that lower expression of Lamin-B1 antibodywas associated with higher tumor grade. The levels of lamin A, on the other hand, were not altered in human Lung Tumors, indicating that the different types of lamins have distinct functions in lung carcinogenesis. Overexpression of Lamin-B1 antibody can also indicate poor prognosis in Colon and Pancreatic Cancers.

Caractéristiques

Type

Rabbit Monoclonal

Clone

RBT-LMNB1

Isotype

IgG

Réactivité

Paraffin, Frozen

Localisation

Nuclear

Contrôle

Colon, Breast, Fallopian Tube, Tonsil, Testis, Transitional Cell Carcinoma, T Cell Lymphoblastic Lymphoma, Colon Adenocarcinoma

Usage prévu

For In Vitro Diagnostic Use