LAG-3 / CD223 (EP294), RMab

Description

Lymphocyte-activation gene 3, also known as LAG-3 and designated as CD223, is a cell surface protein with diverse biologic effects on T cell function encoded by the LAG-3 gene. The gene for LAG-3 lies adjacent to the gene for CD4 on human chromosome 12 (12p13) and is approximately 20% identical to the CD4 gene. LAG-3 antibody is expressed on activated T cells, natural killer cells, B cells and plasmacytoid dendritic cells. The LAG-3 protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg, regulatory T cells, suppressive function. LAG-3 also helps maintain CD8+ T cells in a tolerogenic state and, working with PD-1, helps maintain CD8 exhaustion during chronic viral infection. LAG-3 is known to be involved in the maturation and activation of dendritic cells. Studies have shown that LAG-3 antibody expression is a prognostic indicator of poor treatment outcomes in chronic lymphocytic leukemia, has been associated with higher risk of multiple myeloma, may play a modulating role in autoimmune diabetes and has been identified in a subset of HIV-specific LAG-3(+) CD8(+) T cells that negatively correlated with plasma viral load. IHC studies have shown LAG-3 antibody expression on lymphocytes scattered in renal cell carcinoma, melanoma and lymphomas.

Caractéristiques

Type

Rabbit Monoclonal

Clone

EP294

Isotype

IgG

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic, Membranous

Contrôle

Testis, Lymph Node, Spleen, Lymphoblastic Lymphoma, TCC

Usage prévu

For In Vitro Diagnostic Use