BIO SB Kappa Light Chains (BSB-58), MMab
For In Vitro Diagnostic Use
Description
Kappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, Kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulin. When studying B-cell neoplasms, the determination of light-chain ratios remains the centerpiece. This is sound reasoning because most B-cell Lymphomas express either the kappa light chains antibody or the lambda light chains antibody, whereas reactive proliferations display a mixture of kappa and lambda-positive cells. If only a single light-chain type is detected, a lympho-proliferative disorder is very likely. Monoclonality is determined by a kappa-lambda ratio greater than or equal to 3:1, a lambda-kappa ratio greater than or equal to 2:1, or a monoclonal population of 75% or more of the total population.
Synonymes
Ig κ chain, Ig kappa chain, IGKC, immunoglobulin kappa constant, HCAK1, IGKCD, Km, anti-Kappa Light Chains, anti Kappa Light Chains, anti-klc, anti klc
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- BSB-58
- Isotype
- IgG1/K
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic
- Contrôle
- Tonsil, Lymph Node
- Usage prévu
- For In Vitro Diagnostic Use
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