Islet-1 / ISL1 (EP283), RMab

Description

Islet-1, Insulin gene enhancer protein ISL-1, is a protein that in humans is encoded by the ISL1 gene. This gene encodes a transcription factor containing two N-terminal LIM domains and one C-terminal homeo domain. The encoded protein plays an important role in the embryogenesis of pancreatic islets of Langerhans. ISL1 has been shown to interact with Estrogen Receptor alpha. Islet-1 antibody produces a strong nuclear staining in the islets of normal pancreas and tumor cells of the pancreatic neuroendocrine tumors. Islet-1 has been found to be a reliable marker of pancreatic endocrine tumors and metastasis. It shows a comparable sensitivity and specificity as CDX2 as a marker of ileal and appendiceal neuroendocrine tumors and their metastasis. TTF1 is very rarely expressed in well-differentiated gastroentero-pancreatic endocrine tumors. Therefore, the panel of Islet-1 CDX2, and TTF1 and they may be useful for examining metastasis of well-differentiated endocrine carcinomas of unknown origin.

Caractéristiques

Type

Rabbit Monoclonal

Clone

EP283

Isotype

IgG

Réactivité

Paraffin, Frozen

Localisation

Nuclear

Contrôle

Pancreas, Testis, Thyroid, Cervix, Skin, Pancreatic Neuroendocrine Cancer

Usage prévu

For In Vitro Diagnostic Use