BIO SB INI-1 (25), MMab
For In Vitro Diagnostic Use
Description
The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/ SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratenorial primitive neuroectodermal tumors (sPNETs)) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by INI-1 antibody is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by INI-1 antibody. MRTs also originate from the kidney and soft tissues.
Synonymes
SMARCB1, BAF47, hSNF5, hSNFS, INI1, Integrase interactor 1 protein, malignant rhabdoid tumor suppressor, RDT, Sfh1p, SNF5, SNF5L1, Snr1, sucrose nonfermenting yeast homolog like 1, BRG1 associated factor 47, SNF5 homolog, RTPS1, MRD15, anti-ini1, anti ini1, ini-1, ini1, anti-ini 1, anti-ini-1
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- 25
- Isotype
- IgG2a
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Testis, Brain, Breast, Colon, Kidney, Pituitary, Adrenal, Prostate, Thyroid, Lung, Pancreas, Cervix, Salivary Gland, Astrocytoma, Lymphoblastic Lymphoma, Transitional Cell Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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