IL-6 (BSB-140), MMab

Description

Interleukin-6 is a cytokine that regulates inflammation pathways of the classic and trans-signaling cascades, often involved in metabolic, autoimmune and inflammatory conditions such as IgA nephropathy, lupus nephritis, and chronic kidney disease. The ligation of IL-6/IL-6R activates the JAK/STAT3 (cell survival and proliferation) and MAPK (cell growth and protein production) signaling pathways. IL-6 participates in autoimmune and inflammatory conditions such as arthritis, where it triggers the differentiation of CD4+ T cells into Th17 helper cells, suppresses differentiation into T regulatory cells, and prevents T helper apoptosis along with IL-2. IL-6 also induces differentiation of monocytes into macrophages and uses follicular T helper cells to induce B cell activation, upregulating IgG production. IL-6 antibody reactivity is often found in immune tissues, podocytes, mesangial cells, endothelial and epithelial cells. Il-6 is important in cancer cell growth and suppression of the immune system in the tumor microenvironment, metastasis and renewal of cancer stem cells.

Caractéristiques

Type

Mouse Monoclonal

Clone

BSB-140

Isotype

IgG2b

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic, Membranaous

Contrôle

Testis, Lung, Stomach, Kidney, Transitional Cell Carcinoma

Usage prévu

For In Vitro Diagnostic Use