BIO SB IL-1a (BSB-138), MMab
For In Vitro Diagnostic Use
Description
IL-1a is a dual-function cytokine, acting as a transcription factor and a cell-signaling molecule. The 31 kDa precursor form is biologically active in the cytosol and as a membrane protein. IL-1a can be cleaved by calpain into the biologically active 17 kDa mature form that regulates the expression of NFKB, and IFN-y and its effectors. Cancer stem cells use IL-1a to maintain an inflammatory tumor microenvironment, however IL-1a is also used in recruiting and proliferating immune cells as a necrosis alarmin in damaged epithelia. IL-1a induces NFKB and STAT3 signaling that supports cancer stem cell growth. IL-1a is a major cytokine in innate inflammation signaling pathways, and is thus involved in many inflammatory diseases and reactions to oxidative stress. IL-1a antibody is involved in cancer cell cross-talk and metastasis, and the secretion of cell growth, angiogenesis, and inflammation factors as a Damage-Associated Molecular Pattern. Higher expression of IL-1a has been found in gastric cancer and squamous carcinomas of the head and neck that exhibit distant metastasis. IL-1a has also been associated with tumor de-differentiation and metastasis in breast cancer, and with tumor proliferation and angiogenesis in pancreatic cancer.
Synonymes
il-1a, il1a, anti-il1a, anti-il-1a, il1a antibody, anti-il-1a antibody, cytokine storm, cytokine storm syndrome, cytokine storm antibody, cytokine storm antibodies, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry, IL1A, IL-1α, IL-1alpha, IL-1 alpha, IL-1a, IL-1 a, IL 1α, IL1α, anti-IL-1α, anti IL-1α, anti-IL1A, anti IL1A, anti-IL 1α, anti-IL1α, anti IL 1α, anti IL1α, IL-1F1, Hematopoietin-1, Interleukin-1 alpha, anti-IL-1 alpha, anti IL-1 alpha, anti-IL-1F1, anti IL-1F1, anti-Hematopoietin-1, anti Hematopoietin-1, anti-Interleukin-1 alpha, anti Interleukin-1 alpha, hematopoietin 1, IL 1 alpha, IL 1A, IL1, IL1 ALPHA, IL1F1, interleukin 1 alpha, preinterleukin 1 alpha, pro interleukin 1 alpha
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- BSB-138
- Isotype
- IgG2b
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Membranous
- Contrôle
- Kidney, Colon, Adrenal gland, Testis, Lung
- Usage prévu
- For In Vitro Diagnostic Use
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