BIO SB IgG (BSB-40), MMab
For In Vitro Diagnostic Use
Description
IgG is a monomeric immunoglobulin, built of two heavy chains and two light chains. This is the most abundant immunoglobulin and is approximately equally distributed in blood and tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the placenta and bind to many kinds of pathogens. IgG protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralization of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%). IgG antibody reacts with surface immunoglobulin IgG gamma chains. This antibody is useful when identifying Leukemias, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies.
Synonymes
IGHG3, HDC, Heavy chain disease protein, Ig gamma 3 chain C region, IgG3, immunoglobulin heavy constant gamma 3 G3m marker, anti-igg, anti igg
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- BSB-40
- Isotype
- IgG2a/K
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic
- Contrôle
- Tonsil, Lymph Node, Kidney, Spleen
- Usage prévu
- For In Vitro Diagnostic Use
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