BIO SB HMGA2 (EP398), RMab
For In Vitro Diagnostic Use
Description
High-mobility group AT-hook 2 (HMGA2) belongs to the architectural transcription factor HMGA family and is encoded by the HMGA2 gene. HMGA2 plays a role in chromosomal organization and transcriptional regulation. HMGA2 has three basic DNA-binding domains (AT-hooks) that bind to AT rich regions of nuclear DNA and alter the structure of DNA to promote the assembly of protein complexes that regulate transcription. With few exceptions, HMGA2 is expressed in humans only during early development, and is reduced to undetectable levels of transcription in adult tissues. Elevated expression of HMGA2 antibody is found in a variety of human cancers, correlates with metastasis and poor prognosis for patients. High HMGA2 expression have been reported in Pituitary Adenoma, Thyroid Carcinoma, Triple-Negative Breast Carcinoma, Breast Carcinoma, Lung Adenocarcinoma, Colorectal Carcinoma, Hepatoblastoma, Pancreatic Adenocarcinoma, Conventional and Intramuscular Lipoma, Liposarcoma, Gastric, and Ovarian Tumors and other conditions.. HMGA2 is expressed in most conventional and intramuscular lipomas and can aid in differentiating between Lipomas from dedifferentiated Liposarcomas and distinguishing areas of tumor from normal adipose tissue. In Mesenchymal tumors, HMGA2 antiboy is expressed in benign Fibrous Histiocytoma, Nodular Fasciitis, and Vulvovaginal Angiomyxoma. In Thyroid Carcinomas, upregulation of HMGA2 can distinguish between benign and malignant Follicular neoplasias.
Synonymes
hmga2, anti-hmga2, high-mobility group at-hook 2, anti-high-mobility group, BABL, HMGA2, HMGI C, HMGIC, LIPO, anti-HMGI-C, anti HMGI-C, anti-HMGI C, anti-HMGIC, anti HMGI C, anti HMGIC, anti-HMGA2, anti HMGA2, High Mobility Group AT-Hook 2, High-Mobility Group (Nonhistone Chromosomal) Protein Isoform I-C, High Mobility Group Protein HMGI-C, High Mobility Group AT-Hook Protein 2, HMGA2/KRT121P Fusion, HMGI-C, or SRS5, anti-High Mobility Group AT-Hook 2, anti High Mobility Group AT-Hook 2, anti-High-Mobility Group (Nonhistone Chromosomal) Protein Isoform I-C, anti High-Mobility Group (Nonhistone Chromosomal) Protein Isoform I-C, anti-High Mobility Group Protein HMGI-C, anti High Mobility Group Protein HMGI-C, anti-BABL, anti BABL, anti-LIPO, anti LIPO, anti-High Mobility Group AT-Hook Protein 2, anti High Mobility Group AT-Hook Protein 2, anti-HMGA2/KRT121P Fusion, anti HMGA2/KRT121P Fusion, anti-STQTL9, anti STQTL9, anti-or SRS5, anti or SRS5, high mobility group AT hook 2, High mobility group AT hook protein 2, high mobility group protein HMGI C, high mobility group nonhistone chromosomal protein isoform I C, hmga
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- EP398
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Cervix, Lung Squamous Cell Carcinoma, Papillary Thyroid Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
Intéressé par ce produit ?
Indiquez la référence et le conditionnement souhaités, nous revenons vers vous rapidement.