Histone H3 Phospho (RBT-PHH3), RMab

Description

Phosphohistone-H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the “beads on a string” structure. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis. Phosphohistone-H3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in diagnosis of tumor grades, especially in CNS, skin, gynecologic tissues, soft tissue, and gastrointestinal stromal tumors (GIST).

Caractéristiques

Type

Rabbit Monoclonal

Clone

RBT-PHH3

Isotype

IgG

Réactivité

Human

Localisation

Nuclear

Usage prévu

Histone H3 Phospho (RBT-PHH3), a rabbit monoclonal antibody, is a primary antibody intended for laboratory use by trained laboratory personnel in an immunohistochemical (IHC) assay to qualitatively identify the Histone H3 Phospho protein by light microscopy in normal and/or pathological formalin-fixed, paraffin-embedded (FFPE) human tissue. The clinical interpretation of any staining or its absence should be performed by a qualified pathologist and complemented by morphological studies using proper controls and evaluated within the context of the patient’s clinical history and other diagnostic tests.