GCDFP-15 (23A3), MMab

Description

Gross Cystic Disease is a common premenopausal disorder in which gross cysts are the predominant pathologic lesion. It is characterized by production of a fluid secretion which accumulates in the breast cysts. Gross Cystic Disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15 kDa monomer protein, GCDFP-15. The cells within the body that produce GCDFP-15 appear to be restricted primarily to those with apocrine function such as breast cysts and in apocrine glands in the axilla, vulva, eyelid, and ear canal. Studies have found GCDFP-15 antibody to be a highly specific and sensitive marker for breast cancer. Approximately 70% of breast carcinomas stain positive with antibody to GCDFP-15. In contrast, Colorectal Carcinomas, as well as Mesotheliomas, do not stain with this antibody. Lung Adenocarcinomas rarely stain with this antibody.

Caractéristiques

Type

Mouse Monoclonal

Clone

23A3

Isotype

IgG2a

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic

Contrôle

Breast, Salivary Gland, Breast Carcinoma, Sweat Glands in Skin

Usage prévu

For In Vitro Diagnostic Use