BIO SB GATA-3 (L50-823), MMab
For In Vitro Diagnostic Use
Description
GATA-3 is a mouse monoclonal antibody for immunohistochemistry from Bio SB. Trans-acting T-cell-specific transcription factor, GATA-3 is, a protein that in humans is encoded by the GATA-3 gene. GATA-3 b regulates luminal epithelial cell differentiation in the mammary gland, is an important regulator of T cell development and plays an important role in endothelial cell biology. GATA-3 is one of the three genes mutated in 10% of breast cancers. Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ cancer and luminal androgen responsive cancer in ER-/AR+ tumors. It is highly coexpressed with FOXA1 and serves as negative predictor of basal subtype and HER-2 and is also considered a strong predictor of taxane and platin salts insensitivity. GATA-3 expression is found in urothelial carcinoma, especially in invasive and high grade tumors. Therefore, GATA-3 can be used in a panel of antibodies for diagnosis of unknown primary carcinoma, when carcinomas of the breast or bladder are a possibility. Studies have also shown the utility of GATA-3 in differntiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine, cervix, anus and lung.
Synonymes
gata3, gata-3, gata 3, anti gata3, anti gata-3, anti gata 3, anti-gata3, anti-gata-3, anti-gata 3, GATA binding protein 3, anti-GATA binding protein 3, anti GATA binding protein 3, GATA binding factor 3, trans acting T cell specific transcription factor GATA 3, gata3, anti-gata3, gata3 antibody
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- L50-823
- Isotype
- IgG1/K
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Breast Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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