BIO SB FOXA1 (Polyclonal), RPab
For In Vitro Diagnostic Use
Description
FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. FOXA1 is a downstream target of GATA3 in the mammary gland. FOXA1 antibody expression in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 absence in ERα+ cancer might identify ERa cancers that are resistant to endocrine therapy. In ERα− breast cancer, FOXA1 is highly correlated with improved disease free survival and GATA3. Expression in ERα− cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment.
Synonymes
forkhead box A1, FOXA1, HNF3A, sc101058, HNF-3α, HNF-3alpha, HNF-3 alpha, HNF-3a, HNF-3 a, HNF 3α, HNF3α, anti-HNF-3α, anti HNF-3α, anti-HNF 3α, anti-HNF3α, anti HNF 3α, anti HNF3α, anti-FOXA1, anti FOXA1, anti-HNF3A, anti HNF3A, anti-forkhead box A1, anti forkhead box A1, Forkhead box protein A1, hepatocyte nuclear factor 3 alpha, HNF 3 alpha, HNF 3A, MGC33105, TCF3A, fork head domain, hepatocyte nuclear factor 3 alpha winged helix transcription factor, TCF 3A, HNF3, Transcription factor 3A
Caractéristiques
- Type
- Rabbit Polyclonal
- Clone
- Polyclonal
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear, Cytoplasmic
- Contrôle
- Breast, Prostate, Tonsil, Breast Carcinoma, Prostate Carcinoma, Bladder TCC
- Usage prévu
- For In Vitro Diagnostic Use
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