BIO SB FGFR-3 (BSB-150), MMab
For In Vitro Diagnostic Use
Description
The FGFR3 gene encodes the protein Fibroblast Growth Factor Receptor 3 (FGFR3), part of a family of four fibroblast growth factor receptors that share similar structures and functions. These proteins play a role in several important cellular processes, including regulation of cell growth and proliferation, determination of cell type, angiogenesis, wound healing, and embryo development. Approximately 80% of Non-Muscle Invasive Bladder Cancer (NMIBC) tumors have FGFR3 gene mutations. In addition to high prevalence in Bladder Cancer, somatic mutations in the FGFR3 gene have been associated with Multiple Myeloma and Cervical Cancer. FGFR3 gene aberrations have also been reported in Urothelial, Breast, Head/Neck, Lung, Brain, Gastric, Pancreatic, Colorectal, Kidney, Endometrial, Ovarian, and Cervical Cancers. FGFR-3 antibody, which is highly expressed in Cutaneous Malignant Melanoma (CMM) tissues, is correlated with increased Breslow thickness and lymph node metastasis.
Synonymes
fgfr-3, fgfr 3, fgfr3, anti-fgfr-3, anti-fgfr 3, anti-fgfr3, fibroblast growth actor receptor 3, anti- fibroblast growth factor receptor 3, CD333, FGFR 3, FGFR3, anti FGFR3, anti-FGFR 3, anti FGFR 3, anti-fibroblast growth factor receptor 3, anti fibroblast growth factor receptor 3, anti-CD333, anti CD333, ACH, CEK2, HSFGFR3EX, hydroxyaryl protein kinase, JTK4, tyrosine kinase JTK4
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- BSB-150
- Isotype
- IgG2a
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Membranous
- Contrôle
- Skin, Liver, Brain, Testis, Transitional Cell Carcinoma, Ductal Breast Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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