BIO SB ERCC1 (EP219), RMab
For In Vitro Diagnostic Use
Description
DNA excision repair protein ERCC1 is encoded by the ERCC1 gene on chromosome 19.Excision Repair Cross Complementing 1 (ERCC1) is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 antibody has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.Increased levels of ERCC1 expression may correlate with a lower response to platinum based chemotherapies. Studies have also showed however, that In non-small cell lung carcinoma (NSCLC), surgically removed tumors that receive no further therapy have a better survival if ERCC1-positive than if ERCC1-negative.
Synonymes
ERCC1, anti-ERCC1, anti ERCC1, DNA polymerase eta, Polh, polymerase DNA directed eta RAD 30 related, RAD30 homolog A, RAD30A, Xeroderma pigmentosum variant type protein homolog, XPV, DNA directed DNA polymerase eta
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- EP219
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear
- Contrôle
- Tonsil, Testis, Breast, Prostate, Fallopian Tube, Ovarian Carcinoma, Breast Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
Intéressé par ce produit ?
Indiquez la référence et le conditionnement souhaités, nous revenons vers vous rapidement.