DOG-1 (EP332), RMab

Description

DOG-1 (discovered on GIST 1), a cell-surface protein of unknown function, is expressed strongly on the cell surface of GISTs and is rarely expressed in other soft tissue tumors. Among GIST cases with c-Kit mutations, the DOG1 antibody identified 11% more cases than a c-Kit antibody. The DOG-1 antibody identifies the vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesenchymal and epithelial tumors, and melanomas when compared with c-Kit. The use of this highly-sensitive and specific novel marker should increase the accuracy of GIST diagnosis.

Caractéristiques

Type

Rabbit Monoclonal

Clone

EP332

Isotype

IgG

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic, Membranous

Contrôle

Salivary Gland, Breast, GIST

Usage prévu

For In Vitro Diagnostic Use