BIO SB Desmoglein-3 (EP306), RMab
For In Vitro Diagnostic Use
Description
Desmoglein-3 is a protein that is encoded by the DSG3 gene on Chromosome 18. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component ofdesmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. The Desmoglein-3 antibody has been cited as a superior marker for Lung Squamous Cell Carcinomas, and helps distinguish lung squamous cell carcinoma cases from lung adenocarcinoma. Studies have also shown that a panel consisiting of Desmoglein-3 utilized with Napsin A can be a useful Immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinoma from other subtypes. Lung cases that are typically positive for Desmoglein 3 tend to have a poor clinical outcome.
Synonymes
dsg, CDHF6, DSG3, anti-dsg3, anti dsg3, Desmoglein 3, Pemphigus Vulgaris Antigen (PVA), anti-CDHF6, anti CDHF6, anti-Desmoglein 3, anti Desmoglein 3, anti-Pemphigus Vulgaris Antigen (PVA), anti Pemphigus Vulgaris Antigen (PVA), desmoglein 3 pemphigus vulgaris antigen, PVA
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- EP306
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Membranous
- Contrôle
- Tonsil, Skin, Cervix, Cervical Carcinoma, Lung Squamous Cell Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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