BIO SB DDR1 (BSB-173), MMab
For In Vitro Diagnostic Use
Description
Discoidin Domain Receptor 1 is a collagen activated receptor tyrosine kinase. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung, where it acts on collagen proteins to remodel the Extracellular Matrix. DDR1 may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts. Increased expression of DDR1 has been documented in several types of cancer and fibrotic conditions including skin hypertrophic scars, Idiopathic Pulmonary Fibrosis, cirrhotic liver and renal fibrosis. DDR1 was identified as one of the 72 genes that were significantly upregulated in malignant versus benign Pancreatic Cancer, and high levels of DDR1 mRNA were found in Hepatocellular Carcinomas, which significantly correlated with advanced tumor stage. Overexpression of DDR1 in Lung Cancer cells resulted in a significant increase of cell motility and invasiveness, therefore, poor prognosis for the patients. Dysregulation of DDR1 can cause changes in the ECM that impede drug delivery to tumors, and under-expression of DDR1 is correlated with tissue and organ atrophy.
Synonymes
CD167, DDR1, discoidin domain receptor tyrosine kinase 1, RTK6, anti-DDR1, anti DDR1, Discoidin Domain Receptor 1 (DDR1), anti-Discoidin Domain Receptor 1 (DDR1), anti Discoidin Domain Receptor 1 (DDR1), receptor tyrosine kinase (RTK) DDR-1, anti-discoidin domain receptor tyrosine kinase 1, anti discoidin domain receptor tyrosine kinase 1, anti-CD167, anti CD167, anti-RTK6, anti RTK6, anti-receptor tyrosine kinase (RTK) DDR-1, anti receptor tyrosine kinase (RTK) DDR-1, CAK, CD167 antigen like family member A, cell adhesion kinase, DDR, Discoidin receptor tyrosine kinase, EDDR1, Epithelial discoidin domain receptor 1, epithelial discoidin domain containing receptor 1, HGK2, mammary carcinoma kinase 10, MCK 10, MCK10, NEP, neuroepithelial tyrosine kinase, neurotrophic tyrosine kinase receptor type 4, NTRK4, Protein tyrosine kinase 3A, protein tyrosine kinase RTK 6, PTK3, PTK3A, PTK3A protein tyrosine kinase 3A, TRK E, TRKE, Tyrosine kinase DDR, Tyrosine protein kinase CAK
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- BSB-173
- Isotype
- IgM, kappa
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic
- Contrôle
- Brain, Breast, Colon, Testis
- Usage prévu
- For In Vitro Diagnostic Use
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