BIO SB Cytokeratin 14 (LL002), MMab
For In Vitro Diagnostic Use
Description
Cytokeratin 14 is a Type I polypeptide found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. It is usually found as a heterotetramer with two cytokeratin 5 molecules, and a Type II keratin. Together, they form the cytoskeleton of epithelial cells. Mutations in the genes for these cytokeratins are associated with Epidermolysis Bullosa Simplex. Cytokeratin 14 antibody has been studied as a prognostic marker in Breast Cancer. This antibody labels the basal layer of stratifying squamous and non-squamous epithelia. The staining pattern is cytoplasmic. It recognizes Basal Cell Carcinomas and Squamous Cell Carcinomas. Anti-CK14 has been demonstrated to be useful in differentiating Squamous Cell Carcinomas from other epithelial tumors. This antibody has also been useful in separating oncocytic tumors of the kidney from renal mimics, as well as in determining metaplastic Carcinomas of the Breast.
Synonymes
keratin 14, KRT14, anti-Cytokeratin 14, anti Cytokeratin 14, anti-KRT14, anti KRT14, anti-Keratin 14, anti Keratin 14, CK 14, CK14, anti-ck14, anti ck14, anti-ck 14, cytokeratin 14, EBS3, EBS4, K14, keratin 14 epidermolysis bullosa simplex Dowling Meara Koebner, Keratin type I cytoskeletal 14, NFJ
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- LL002
- Isotype
- IgG3
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic
- Contrôle
- Squamous Mucosa, Prostate, Breast, Tonsil, Salivary Gland, Skin, Cervix Carcinoma, Squamous Carcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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