CXCR4 / CD184 / Fusin (EP394), RMab

Description

Chemokine Receptor 4 (CXCR4, also CD184 or Fusin) is a homeostatic chemokine. Its major function is to regulate hematopoietic cell trafficking and secondary lymphoid tissue architecture. CXCR4 is widely expressed on Hematopoietic cells, including CD34+ HSC, T Lymphocytes, B Lymphocytes, Monocytes, Macrophages, Neutrophils, and Eosinophils, as well as organs including Brain, Heart, Colon, and Kidney, and Endothelial cells, Epithelial cells, and Smooth Muscle progenitors. With roles in cell homing and tissue repair, CXCR4 is involved in cancer cell physiology, survival, and metastasis in >20 cancer types. CXCR4 induces and recruits stem cells and promotes angiogenesis in tumors, and responds to CXCL12 expression to promote metastasis in cancers of the Bone, Brain, Breast, Lung, Liver, Kidney, and other tissues. The SDF-1/CXCR4 axis plays a crucial role in engraftment, where CXCR4 antibody expression is correlated with inflammation and graft rejection. The most studied role for CXCL12 chemokine and its receptor CXCR4 in Breast Cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for Breast Cancer cell migration to other sites such as Lung, Bone, and Lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 antibody is being considered a prognostic marker in Breast Cancer.

Caractéristiques

Type

Rabbit Monoclonal

Clone

EP394

Isotype

IgG

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic, Membranous

Contrôle

Fallopian Tube, Adrenal Gland, Stomach, Kidney, Transitional Cell Caricnoma, T Cell Lymphoblastic Lymphoma, Tonsil, Testis

Usage prévu

For In Vitro Diagnostic Use