Collagen IV (RBT-COL4), RMab

Description

Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 25% of the total protein content. Collagen IV is a major constituent of the basement membranes, along with laminins and enactins. It is composed of the alpha 1 IV chain and alpha 2 IV chain in a 2:1 ratio. It can form insoluble fibers with high tensile strength. Normal tissue immunostained with this Collagen IV antibody is consistent with the sites of mesenchymal elements and epithelial basal laminae. Collagen IV antibody is useful in detecting the loss of parts of basement membrane in carcinomas. Collagen IV can also be useful in the classification of soft tissue tumors; schwannomas, leiomyomas, and their well-differentiated malignant counterparts usually immunoreact to this antibody. The vascular nature of neoplasms, hemangiopericytoma, angiosarcoma and epithelioid hemangioendothelioma can be observed with this antibody.

Caractéristiques

Type

Rabbit Monoclonal

Clone

RBT-COL4

Isotype

IgG

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic, Membranous

Contrôle

Muscle, Lung, Breast, Placenta, Testis, Transitional Cell Carcinoma, T Cell Lymphoblastic Lymphoma

Usage prévu

For In Vitro Diagnostic Use