Claudin-7 (EP399), RMab

Description

Claudin-7 is encoded by the CLDN7 gene and is a member of the claudin family. Claudin-7 is a component of tight junctions and plays important roles in maintaining cell polarity and tightly connecting the barriers between cells. Abnormal Claudin-7 protein expression is closely related to tumor occurrence, development, and metastasis. Claudin-7 expression is down-regulated in Colorectal Cancer (CRC) and Lung Cancer tissues and loss of Claudin-7 is associated with the degree of cancer cell differentiation and metastasis. Claudin-7 may serve as a tumor suppressor, as it is involved in pathways of cell proliferation and epithelial barrier formation through Integrin signaling networks. The deficient extracellular matrix in cells with low Claudin-7 antibody expression promotes abnormal growth patterns and metastasis in Ductal and Lobular Breast Carcinomas, and Claudin-7 expression is lost in ~50% of primary tumors in Breast Cancers. While Claudin-7 downregulation was found in Esophageal, Head/Neck, and Prostate Cancers, overexpression of Claudin-7 is found in many Ovarian Cancers and may also lead to increased tumor invasiveness.

Caractéristiques

Type

Rabbit Monoclonal

Clone

EP399

Isotype

IgG

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic, Nuclear, Membranous

Contrôle

Breast, Colon, Falopian Tube, Pancreas, Kidney, Transitional Cell Carcinoma

Usage prévu

For In Vitro Diagnostic Use