BIO SB Claudin-4 (EP417), RMab
For In Vitro Diagnostic Use
Description
Claudin-4 belongs to the tight-junction-associated protein group. The expression of Claudin-4 is found in most epithelial cells, but not in Mesothelial cells. Detection of Claudin-4 via IHC allows distinguishing Lung Adenocarcinoma from malignant Mesothelioma in tissue samples. In malignant effusions, Claudin-4 detection effectively identifies Adenocarcinoma from malignant Mesothelioma with high sensitivity and specificity. Another study showed that Claudin-4 detection is an independent positive prognostic factor for Gastric Carcinoma, which restricts the migration of gastric cancer cells. Claudin-4 overexpression in gastric cancer cells is associated with epigenetic derepression and contributes to the suppression of gastric cancer progression and positive prognosis of the patient. On the other hand, Claudin-4 expression is downregulated in epithelial malignancies and in precancerous lesions. In addition, Claudin-4 plays an important role in tumor cell invasion and metastasis. Claudin-4 is a highly specific and sensitive marker to differentiate epithelioid mesotheliomas from metastatic carcinomas.
Synonymes
claudin 4, claudin-4, CLDN4, claudin4, anti-claudin-4, anti claudin-4, anti-claudin 4, anti-claudin4, anti claudin 4, anti claudin4, anti-CLDN4, anti CLDN4, Clostridium perfringens enterotoxin receptor, Clostridium perfringens enterotoxin receptor 1, CPE R, CPE receptor, CPER, CPETR, CPETR1, hCPE R, WBSCR8, Williams Beuren syndrome chromosomal region 8 protein
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- EP417
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Membranous
- Contrôle
- Thyroid, Placenta, Kidney, Colon, Breast, Tonsil, Ductal Breast Carcinoma, Lung Neuroendocrine Cancer, Pancreatic Adenocarcinoma, Colon Adenocarcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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