BIO SB CITED1 (BSB-177), MMab
For In Vitro Diagnostic Use
Description
CITED1 is a transcriptional coactivator of the p300/CBP-mediated transcription complex. It enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. It also stimulates estrogen-dependent transactivation activity mediated by estrogen receptor signaling by stabilizing the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. CITED1 also positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex, and associates with chromatin to the estrogen-responsive TGF-alpha promoter region in an estrogen-dependent manner. Additionally, CITED1 induces transcription from estrogen-responsive promoters and protection against cell death in breast cancer, potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter, and acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. Current investigations suggest that it may have a role in pigmentation of melanocytes.
Synonymes
anti-cited1, anti cited1, CITED1, anti-msg1, anti msg1, cbp p300 interacting transactivator 1, Cbp p300 interacting transactivator with Glu Asp rich carboxy terminal domain 1, melanocyte specific gene 1, melanocyte specific protein 1, MSG1
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- BSB-177
- Isotype
- IgG2a, Kappa
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Nuclear
- Contrôle
- Testis, Renal tubules
- Usage prévu
- For In Vitro Diagnostic Use
Intéressé par ce produit ?
Indiquez la référence et le conditionnement souhaités, nous revenons vers vous rapidement.