CDX2 (EP25), RMab

Description

CDX2 is a rabbit monoclonal antibody for immunohistochemistry from Bio SB. CDX2 is a caudal-type homeobox gene that encodes an intestine-specific transcription factor expressed early in intestinal development and that may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demon-strated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer. It is not expressed in the normal gastric mucosa. Loss of CDX2 protein expression has been correlated with loss of differentiation in colorectal cancers. The CDX2 antibody has been useful in distinguishing the gastrointestinal origin of metastatic adenocarcinomas and carcinoids. Studies have shown that the CDX2 antibody is a superior marker compared to CK20. A high percentage of mucinous carcinomas of the ovary also stain positively with this antibody, as well as Carcinomas from the upper gastrointestinal tract.

Caractéristiques

Type

Rabbit Monoclonal

Clone

EP25

Isotype

IgG

Réactivité

Paraffin, Frozen

Localisation

Nuclear

Contrôle

Adenocarcinoma of Colon, Normal Colon

Usage prévu

For In Vitro Diagnostic Use