BIO SB CDK2 (RBT-CDK2), RMab
For In Vitro Diagnostic Use
Description
CDK2 (also known as Cyclin-dependent kinase 2 or cell division protein kinase 2) is a 33 kDa enzyme that in humans is encoded by the CDK2 gene on Chromosome 12. CDK2 is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, and is essential for the cellular G1/S transition. Studies indicate that over expression of CDK2 may cause the abnormal regulation of cell-cycle, which would could directly contribute to hyper-proliferation of cancerous cells. HOX genes, which play a key role in cell differentiation and morphogenisis, are regulated by CDK2. Studies have shown that HOXA7 promoted cell proliferation (mediated by cyclin E1/CDK2) is evident in cases of Hepatocellular carcinoma, indicating that CDK2 antibody may prove to be a useful marker in such cases.
Synonymes
CDK2, cyclin dependent kinase 2, sc6248, Cdk 2, anti-Cdk2, anti Cdk2, anti-cyclin dependent kinase 2, anti cyclin dependent kinase 2, cdc2 related protein kinase, cell devision kinase 2, Cell division protein kinase 2, p33 protein kinase, p33 CDK2
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- RBT-CDK2
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Nuclear
- Contrôle
- Testis, Tonsil, Prostate
- Usage prévu
- For In Vitro Diagnostic Use
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