BIO SB CD75 (LN-1), MMab
For In Vitro Diagnostic Use
Description
CD75, also known as CDw75 or Beta-galactoside alpha-2,6-sialyltransferase 1( ST6GAL-1) is an enzyme that in humans is encoded by the ST6GAL1 gene. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. CD75 antibody labels germinal centre B-cells as well as epithelial cells, however is absent in plasma cells. It reacts with RBC precursors of bone marrow, ductal and ciliated epithelial cells of kidney, breast, prostate, pancreas, lung, and with glioblastomas, astrocytomas, and Reed Sternberg cells in lymphocyte predominant Hodgkin’s disease. CD75 antibody has been shown to be a helpful for ascribing a B-cell phenotype in known lymphoid tissues.
Synonymes
cd75, anti-cd75, anti cd75, alpha 2 6 ST, AW742324, beta galactoside alpha 2 6 sialyltransferase 1, Cd75, CMP N acetylneuraminate beta galactosamide alpha 2 6 sialyltransferase 1, MGC116663, OTTMUSP00000031674, OTTMUSP00000032134, Sialyltransferase 1, SIAT1, ST6 beta galactosamide alpha 2 6 sialyltranferase 1, St6gal, ST6Gal I, ST6GAL1, ST6GalI, Alpha 26 ST, SIAT 1, CMP N acetylneuraminate beta galactosamide alpha 2 6 sialyltransferase, Beta galactoside alpha 26 sialyltransferase, B cell antigen, CMP N acetylneuraminate beta galactosamide alpha 2 6 sialyltransferase Beta galactoside alpha 26 sialyltransferase, ST6N, MGC48859, B cell antigen CD75, sialyltransferase 1 beta galactoside alpha 2 6 sialyltransferase, alpha 2 6 ST 1
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- LN-1
- Isotype
- IgG1/K
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Membranous
- Contrôle
- Liver, Prostate, Kidney Tonsil
- Usage prévu
- For In Vitro Diagnostic Use
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