BIO SB CD74 (LN2), MMab
For In Vitro Diagnostic Use
Description
CD74, also known as the MHC Class II-associated invariant chain (II), is a Type II transmembrane protein which binds to the peptide-binding groove of newly-synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen-presenting cells such as B-lymphocytes (from before the pre-B-cell stage to before the plasma-cell stage), macrophages and monocytes, together with many epithelial cells. CD74 antibody stains predominantly germinal-center lymphocytes and B-cell lymphomas but rarely T-cell lymphomas. It stains the cell membrane but a paranuclear globular labeling is also noted. CD74 antibody is useful in differentiating Atypical Fibroxanthoma from Malignant Fibrous Histiocytoma, as well as Small-cell Lung Carcinoma from Non-small cell Lung Carcinomas.
Synonymes
CD74, HLA class II histocompatibility antigen gamma chain, anti-CD74, anti CD74, anti-HLA class II histocompatibility antigen gamma chain, anti HLA class II histocompatibility antigen gamma chain, CD74 antigen invariant polypeptide of major histocompatibility complex class II antigen associated, CD74 molecule major histocompatibility complex class II invariant chain, DHLAG, gamma chain of class II antigens, HLA DR antigens associated invariant chain, HLA DR gamma, HLADG, Ia antigen associated invariant chain, Ia associated invariant chain, Ia GAMMA, Ii, MHC HLA DR gamma chain, p33, FLJ98970
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- LN2
- Isotype
- IgG1/K
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Membranous
- Contrôle
- Tonsil, Lymph Node
- Usage prévu
- For In Vitro Diagnostic Use
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