CD7 (EP132), RMab

Description

CD7 is a 40 kDa transmembrane, single-chain glycoprotein, which is a member of the immunoglobulin gene superfamily. It is expressed in the majority of immature and mature T-lymphocytes and T-cell Leukemia. CD7 is also found in natural killer cells, a small subpopulation of normal B-cells and in malignant B-cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interactions during early lymphoid development. CD7 antibody is a consistently-expressed T-cell antigen in Lymphoblastic Lymphomas and Leukemias; therefore, it is a useful marker in the identification of such neoplastic proliferations. CD7 antibody is expressed in the majority of mature peripheral T-cells, the majority of post-thymic T-cells, NK cells, some myeloid cells, T-cell Acute Lymphoblastic Leukemia/Lymphoma, Acute Myelogenous Leukemia and Chronic Myelogenous Leukemia. Interestingly, CD7 is conspicuously absent in adult T-cell Leukemia/Lymphoma and is not expressed in Sezary cells.

Caractéristiques

Type

Rabbit Monoclonal

Clone

EP132

Isotype

IgG

Réactivité

Paraffin, Frozen

Localisation

Membranous

Contrôle

Tonsil, Lymph Node, Colon, Liver, Spleen, Bone Marrow, Lymphoblastic, Lymphoma

Usage prévu

For In Vitro Diagnostic Use