BIO SB CD68 (KP-1), MMab
For In Vitro Diagnostic Use.
Description
The CD68 antigen is a heavily glycosylated trans-membrane protein of 87-115 kDa which is specifically expressed by tissue macrophages, Langerhans cells and, at low levels, by dendritic cells. CD68 could play a role in phagocytic activities of tissuemacrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 antibody marks cells of monocyte/macrophage lineage. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, granulocytes and their precursors; Lymphomas are negative or show a few granules. This antibody may be useful for the identification of Myelomonocytic and Histiocytic Tumors. CD68 antibody may help to distinguish Malignant Fibrous Histiocytoma from other Pleomorphic Sarcomas. However, since CD68 detects a formalin-resistant epitope that may be associated with lysosomal granules, other lysosome-rich cells may also produce positive results.
Synonymes
CD68, Gp110, SCARD1, LAMP4, anti-CD68, anti CD68, anti-GP110, anti GP110, anti-LAMP4, anti LAMP4, anti-SCARD1, anti SCARD1, CD68 antigen, CD68 molecule, DKFZp686M18236, macrophage antigen CD68, macrosialin, scavenger receptor class D member 1
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- KP-1
- Isotype
- IgG1
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Membranous
- Contrôle
- Tonsil, Lymph Node
- Usage prévu
- For In Vitro Diagnostic Use.
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