BIO SB CD45 (2B11 & PD7/26), MMab
For In Vitro Diagnostic Use
Description
The CD45 antigen is a protein which was originally called Leukocyte Common Antigen. It is a Type I transmembrane protein which is in various forms present on all differentiated hematopoietic cells except erythrocytes and assists in the activation of those cells (a form of co-stimulation). It is expressed in Lymphomas, B-cell Chronic Lymphocytic Leukemia, Hairy Cell Leukemia, and Acute Non-lymphocytic Leukemia. CD45 antibody routinely used to aid in the differential diagnosis of undifferentiated neoplasms, whenever malignant Lymphoma is suspected by the morphological or clinical data. It is a highly specific antibody; thus, a positive result is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin’s Disease, some T-cell Lymphomas and some Leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is exclusively expressed by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes, erythrocytes and plasma cell precursors.
Synonymes
protein tyrosine phosphatase receptor type C, PTPRC, sc1187, sc-1187, 1187, anti-CD45, anti CD45, anti-PTPRC, anti PTPRC, anti-protein tyrosine phosphatase receptor type C, anti protein tyrosine phosphatase receptor type C, B220, CD45, CD45 antigen, CD45R, GP180, L CA, LCA, Leukocyte common antigen, LY5, protein tyrosine phosphatase receptor type c polypeptide, T200, T200 glycoprotein, T200 leukocyte common antigen, receptor type tyrosine protein phosphatase C
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- 2B11 & PD7/26
- Isotype
- IgG1/K
- Réactivité
- Paraffin, Frozen
- Localisation
- Membranous
- Contrôle
- Tonsil, Lymph Node, Spleen, Thymus
- Usage prévu
- For In Vitro Diagnostic Use
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