BIO SB CD43 (MT1), MMab
For In Vitro Diagnostic Use.
Description
CD43 (leukosialin, sialophorin, or leukocyte sialoglycoprotein) is one of the major glycoproteins expressed in all thymocytes and T-cells. It plays a role in the physicochemical properties of the T-cell surface and in lectin binding. During T-cell activation, CD43 is actively removed from the T-cell antigen-presenting cell contact site, suggesting a negative regulatory role in adaptive immune response. CD43 antibody has been found useful in identification and classification of T-cell malignancies and low grade B-cell Lymphomas. CD43 antibody expression is seen in some cases of B-cell Lymphocytic Lymphoma and Centrocytic Lymphoma. When used in combination with CD45 and CD20, effective immunophenotyping of the majority of Lymphomas can be obtained. Co-staining of a lymphoid infiltrate with CD20 and CD3 argues against a reactive process and favors Lymphoma.
Synonymes
CD43, Galactoglycoprotein, GALGP, GPL115, Leukocyte sialoglycoprotein, leukosialin, LSN, sialophorin, sialophorin gpL115 leukosialin CD43, sialophorin leukosialin CD43, anti-cd34, anti cd34
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- MT1
- Isotype
- IgG1
- Réactivité
- Paraffin, Frozen
- Localisation
- Membranous
- Contrôle
- Tonsil, Lymph Node
- Usage prévu
- For In Vitro Diagnostic Use.
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