BIO SB CD33 (RBT-CD33), RMab
For In Vitro Diagnostic Use
Description
CD33 (gp62 or siglec-3) is a glycosylated transmembrane protein that is a member of the sialic acid-binding immunoglobulin-like lectin (siglec) family. The genomic locus of this protein has been mapped to chromosome 19q13.1-3.5. The function of CD33 is not known, but it may have a role in cell-to-cell adhesion. In maturing granulocytic cells, there is progressive down-regulation of CD33 from the blast stage to mature neutrophils. However, in monocytes and macrophages/histiocytes, strong expression of CD33 is maintained throughout maturation. Detection of CD33 using monoclonal antibodies has been a critical component in immunophenotyping acute leukemias, particularly Acute Myeloid Leukemias.
Synonymes
CD33 antigen gp67, CD33 molecule, FLJ00391, gp67, Myeloid cell surface antigen CD33, p67, sialic acid binding Ig like lectin 3, Siglec 3, SIGLEC3, anti-cd33, anti cd33
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- RBT-CD33
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Membranous
- Contrôle
- Placenta, Myometrium, Lung, Colon, Spleen, Lymph Node, Tonsil, Acute Myeloid Leukemia
- Usage prévu
- For In Vitro Diagnostic Use
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