CD137 / TNFRSF9 (BSB-159), MMab

Description

CD137, or tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as 4-1BB, is encoded by the TNFRSF9 gene on chromosome 1p36.23. CD137/TNFRSF9 is expressed on the surface of certain immune cells, such as Follicular Dendritic Cells, Monocytes, Mast Cells and Granulocytes. CD137/TNFRSF9 is barely detected on resting T cells or T-cell lines, and expression of CD137 is therefore activation dependent. It is found on activated CD4+, CD8+ or Natural Killer Cells. Activation of CD137 by its ligand, CD137L, upregulates survival genes, enhances cell division, induces cytokine production, and prevents activation-induced cell death in T cells. One study demonstrated CD137 antibody positive IHC staining in a majority of Classical Hodgkin Lymphoma (CHL) tissues, indicating its usefulness as a diagnostic biomarker for CHL. CD137/TNFRSF9 was also found to be a highly specific immunohistochemical marker of Neoplastic Follicular Dendritic Cells. Another study investigated CD137/TNFRSF9 via IHC in malignant tumor cells and found that there was an enhanced expression of CD137/TNFRSF9 in blood vessel cells of malignant tumors compared to blood vessel cells in benign tumors or inflammatory tissues. Further studies indicate the value of CD137 antibody as a prognostic marker in Diffuse Large B-cell Lymphomas, tumor cell differentiation in Gastric Cancer as well as the correlation between CD137/TNFRSF9 expression and bone metastasis of Breast Cancer. CD137/TNFRSF9 is considerably up-regulated in human Gliomas when compared with normal brain tissue. In addition, data provides evidence for an immune cell-independent de novo expression pattern of CD137/TNFRSF9 in mainly non-neoplastic reactive astrocytes and excludes classic immunological cell types, namely lymphocytes and microglia as the source of CD37/TNFRSF9. Moreover, TNFRSF9 is predominantly expressed in a perivascular and peritumoural distribution with significantly higher expression in IDH-1 mutant gliomas.

Caractéristiques

Type

Mouse Monoclonal

Clone

BSB-159

Isotype

IgM

Réactivité

Paraffin, Frozen

Localisation

Nuclear, Membranous

Contrôle

Colon, Stomach, Tonsil, Testis, Transitional Cell Carcinoma, DBC, Hepatocellular Carcinoma, Diffuse Type Gastric Carcinoma

Usage prévu

For In Vitro Diagnostic Use