Caldesmon (BSB-19), MMab

Description

Caldesmon antibody, also known as Caldesmon 1, or CALD1, is a human gene. Caldesmon is a calmodulin-binding protein. Like Calponin, Caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle. This gene encodes a Calmodulin and actin-binding protein that play an essential role in the regulation of smooth muscle and nonmuscle contraction. Two closely-related variants of human Caldesmon have been identified. The h-Caldesmon variant (120–150 kD) is predominantly expressed in smooth muscle, whereas I-Caldesmon (70–80 kD) is found in non-muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. Caldesmon antibody recognizes only the h-Caldesmon variant. Caldesmon antibody labels smooth muscle and tumors of smooth muscle, myofibroblastic, and myoepithelial differentiation. Anti-Caldesmon has also been used to differenti-ate Epithelioid Mesothelioma from Serous Papillary Carcinoma of the ovary.

Caractéristiques

Type

Mouse Monoclonal

Clone

BSB-19

Isotype

IgG1/K

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic

Contrôle

Appendix, Uterus, Leiomyoma

Usage prévu

For In Vitro Diagnostic Use