BIO SB Cadherin-17 / LI-Cadherin (EP86), RMab
For In Vitro Diagnostic Use
Description
LI-Cadherin, also known as Cadherin-17, is part of the cadherin superfamily and is a calcium-dependent, membrane-associated glycoprotein. Cadherins are responsible for mediating cell-cell adhesion and are important for the structural integrity of epithelia. LI-Cadherin consists of an extracellular region containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. It is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. It may play a role in the morphological organization of liver and intestine. In normal tissues, the LI-Cadherin antibody labels epithelial cells in the gastrointestinal tract and pancreatic duct, but not in kidney, liver and other tissues. In tumors, LI-Cadherin is expressed on adenocarcinoma of the digestive system, including liver cancer. It is a sensitve marker for the identification of gastric intestinal metaplasia and well differentiated adenocarcinomas.
Synonymes
CDH16, HPT1, sc393533, LI cadherin, LIcadherin, CDH17, anti CDH16, anti CDH17, anti HPT1, anti LI cadherin, anti LI-cadherin, anti LIcadherin, anti-CDH16, anti-CDH17, anti-HPT1, anti-LI cadherin, anti-LI-cadherin, anti-LIcadherin, cadherin 17 LI cadherin liver intestine, HPT 1, cadherin 17, cadherin-17, anti-cadherin 17, anti-cadherin-17, cad 17, cad-17, anti-cad 17, anti-cad17
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- EP86
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic
- Contrôle
- Colon
- Usage prévu
- For In Vitro Diagnostic Use
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