CA15-3 (DF3), MMab

Description

CA 15-3 antibody has been used for evaluating the primary site of a metastatic carcinoma of unknown origin and distinguishing between benign and malignant lesions. It is believed that CA 15-3 reacts primarily with the DF3-antigen, a 300 kDa mucin-like glycoprotein present on the apical border of secretory mammary epithelial cells. CA 15-3 has been detected with immunohistochemistry in a wide spectrum of carcinomas, including Breast Carcinomas (ductal and lobular), Sarcomas (Synovial Sarcoma and Malignant Fibrous Histiocytomas), and Lung Carcinomas. CA 15-3 antibody can be used as a supplementary marker for epithelial differentiation. CA 15-3 does not stain Melanomas or Ewing’s Sarcomas. Approximately 30% of Hepatocellular Carcinomas are positive for CA 15-3.

Caractéristiques

Type

Mouse Monoclonal

Clone

DF3

Isotype

IgG1

Réactivité

Paraffin, Frozen

Localisation

Cytoplasmic, Membranous

Contrôle

Kidney, Breast, Pancreas, Lymph Node, Cervix, Salivary Gland, Bladder TCC

Usage prévu

For In Vitro Diagnostic Use