BIO SB C3c (Polyclonal), RPab
For In Vitro Diagnostic Use. This antibody is intended for use in Immunohistochemical (IHC) and Immunofluorescence (IF) applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.
Description
Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. C3 glomerulopathy was recently coined to describe renal biopsy appearances characterized by the presence of glomerular deposits composed predominantly of C3 in the absence of significant amounts of Ig. The presence of C3 antibody in the absence of Ig suggests activation of complement by antibody-independent pathways, typically the alternative pathway, and many patients with this type of renal lesion have evidence of genetic or acquired alternative pathway dysregulation. C3 glomerulopathy has been further divided into dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) based on electron microscopy (EM) appearances. The underlying genetic defect has been identified in some hereditary forms of C3GN such as CFHR5 nephropathy. Lupus nephritis is an inflammation of the kidneys caused by Systemic Lupus Erythematosus. Immunofluorescence reveals positively for IgG, IgA, IgM, C3, and C1q.
Synonymes
C3, complement C3, CPAMD1, sc55458, sc-55458, 55458, anti-C3, anti C3, anti-Complement C3, anti Complement C3, anti-CPAMD1, anti CPAMD1, acylation stimulating protein cleavage product, ARMD9, ASP, C3 and PZP like alpha 2 macroglobulin domain containing protein 1, C3a anaphylatoxin, Complement C3 alpha chain, Complement C3 beta chain, Complement C3b alpha chain, Complement C3c alpha chain fragment 1, Complement C3c alpha chain fragment 2, Complement C3d fragment, Complement C3dg fragment, Complement C3f fragment, Complement C3g fragment, complement component 3, complement component C3, AHUS5
Caractéristiques
- Type
- Rabbit Polyclonal
- Clone
- Polyclonal
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Membranous
- Contrôle
- Placenta, Kidney, Fallopian Tube, Lupus Erythematosus
- Usage prévu
- For In Vitro Diagnostic Use. This antibody is intended for use in Immunohistochemical (IHC) and Immunofluorescence (IF) applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.
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