BIO SB Bcl-10 (BSB-22), MMab
For In Vitro Diagnostic Use.
Description
bcl-10 (also known as B-cell lymphoma/leukemia 10) is a 233 amino acid protein encoded by the BCL10 gene on Chromosome 1. The protein encoded by this gene contains a caspase recruitment domain , and has been shown to induce apoptosis and activate NF-kappaB. This protein is reported to interact with caspase recruitment domains (CARD) containing proteins including CARD9, 10, 11 and 14. These proteins function as upstream regulators in NF-kappaB signaling. Studies have shown that bcl-10 plays a critical role in the development of mucosa associated lymphoma tissue (MALT) lymphoma, and can be utilized in the classification of lymphomas. The bcl-10 antibody labels subpopulations of normal B and T cells. In MALT lymphomas with the t(1;14) translocation, the antibody strongly labeled the nuclei and cytoplasm, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
Synonymes
bcl10, anti-bcl10, anti-bcl-10, BCL10, sc5273, sc-5273, 5273, anti-Bcl10, anti Bcl10, BCL10 immune signaling adaptor, anti-BCL10 immune signaling adaptor, anti BCL10 immune signaling adaptor, B cell CLL lymphoma 10, B cell lymphoma leukemia 10, Bcl 10, c E10, CARD containing molecule enhancing NF kB, CARD containing apoptotic signaling protein, CARD containing proapoptotic protein, CARD like apoptotic protein, CARMEN, caspase recruiting domain containing protein, cCARMEN, CED 3 ICH 1 prodomain homologous E10 like regulator, Cellular homolog of vCARMEN, cellular E10, CIPER, CLAP, hCLAP, mammalian CARD containing adapter molecule E10, mE10
Caractéristiques
- Type
- Mouse Monoclonal
- Clone
- BSB-22
- Isotype
- IgG1/K
- Réactivité
- Paraffin, Frozen
- Localisation
- Nuclear, Cytoplasmic
- Contrôle
- Tonsil, Kidney, Cervix, bladder TCC, MALT Lymphomas
- Usage prévu
- For In Vitro Diagnostic Use.
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