BIO SB Bax (E63), RMab
For In Vitro Diagnostic Use
Description
Bax is a protein of the bcl-2 gene family. It promotes apoptosis by competing with bcl-2 proper. The Bax gene contains a small promoter element that complements a binding domain on the multi-faceted p53 tumor suppressor. Wild-type p53 has been demonstrated to upregulate the transcription of a chimeric reporter plasmid, utilizing the consensus promoter sequence of Bax approx. 50-fold over mutant p53. Mutations in this consensus sequence eliminate transcription of the reporter gene. Thus, it is likely that p53 promotes Bax’s apoptotic faculties in vivo as a primary transcription factor. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial mem-branes, inducing mitochondrial damage and cell death in a caspase-independent manner. The Bax antibody plays a critical role in the Bax-mediated apoptosis pathway by dimerizing with BclxL, causing the displacement of Bax. The displacement of Bax allows apoptosis to proceed.
Synonymes
BAX, BCL2L4, sc7480, sc-7480, 7480, anti-Bax, anti Bax, anti BCL2 associated X, anti BCL2L4, anti-BCL2 associated X, anti-BCL2L4, BCL2 associated X, Dmelanogaster 1 1ogre gene for conceptual protein of 1 1ogre locus BAX, Dmelanogaster 1 1 ogre gene for conceptual protein of 1 1 ogre locus BAX, Apoptosis regulator BAX, bcl 2 like protein 4
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- E63
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Cell Membranous
- Contrôle
- Breast, Tonsil, Cervix, Hodgkin’s Lymphoma
- Usage prévu
- For In Vitro Diagnostic Use
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