BIO SB AMACR / P504S (13H4), RMab
For In Vitro Diagnostic Use
Description
AMACR (P504S) is an acronym for the protein alpha-methylacyl CoA racemase that helps to metabolize certain fatty acids within the body. AMACR has been recently described as a prostate cancer-specifi c gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in Prostatic Adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of the prostate: High-Grade Prostatic Intraepithelial Neoplasia (PIN) and Atypical Adenomatous Hyperplasia. Several studies have suggested that AMACR can be used as a prostate cancer biomarker. High expression of AMACR antibody (P504S) is usually found in Prostatic Adenocarcinoma but not in benign prostatic tissue by immunohistochemical staining in paraffin-embedded tissues. Using AMACR as a positive marker along with basal-cell staining (34βE12 or p63) as a negative marker could help to confirm the diagnosis of small foci of Prostate Carcinoma on needle biopsies.
Synonymes
AMACR, sc81710, sc-81710, 81710, 2 methylacyl CoA racemase, alpha methylacyl CoA racemase, CBAS4, RACE, RM, AMACRD, amacr, alpha-methylacyl coa racemase, anti-amacr, anti-alpha-methylacyl
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- 13H4
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic
- Contrôle
- Kidney, Liver, Salivary Gland, Prostate Lesions, Prostatic Adenocarcinoma
- Usage prévu
- For In Vitro Diagnostic Use
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