BIO SB ALK-1 (EP302), RMab
For In Vitro Diagnostic Use
Description
Anaplastic Lymphoma Kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 t(2;5), the ALK gene fuses with the NPM gene. The chimeric product (NPM ALK) resulting from t(2;5) translocation is a protein of 80 kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK. ALK-1 antibody recognizes a human p80 protein, identified as a hybrid of the Anaplastic Lymphoma Kinase (ALK) gene and the Nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of Large-Cell Lymphomas. ALK-1 is detected in 60% of Anaplastic Large-Cell Lymphomas and has proven to indicate a better prognosis in the ALK-1 (+) group.
Synonymes
CD246, ALK, anti-ALK, anti ALK, ALK Receptor Tyrosine Kinase (RTK), anti-ALK Receptor Tyrosine Kinase (RTK), anti ALK Receptor Tyrosine Kinase (RTK), ALK RTK, type 1 receptor tyrosine kinase ALK, anti-CD246, anti CD246, anti-ALK RTK, anti ALK RTK, anti-type 1 receptor tyrosine kinase ALK, anti type 1 receptor tyrosine kinase ALK, anaplastic lymphoma receptor tyrosine kinase, NBLST3
Caractéristiques
- Type
- Rabbit Monoclonal
- Clone
- EP302
- Isotype
- IgG
- Réactivité
- Paraffin, Frozen
- Localisation
- Cytoplasmic, Nuclear
- Contrôle
- Anaplastic Large Cell Lymphoma
- Usage prévu
- For In Vitro Diagnostic Use
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